top of page

Mammalian Cell Combinatorial Library

Picture1.jpg

Directed evolution is an effective way of protein engineering and typically performed in microbial systems. Even mammalian cells support protein folding, proper post-translational modifications, and cellular signaling all critical for studying mammalian biology and developing therapeutics, conducting directed evolution in mammalian cells is largely handicapped due to lack of a robust method to construct high quality libraries. We develop platform technologies that meet all desired criteria of an ideal library construction in mammalian cells – single variant per cell, accurate genomic integration, uniform transcription level, and large diversity (Nucleic Acid Res, 2023; Front. Bioeng. Biotechnol., 2024). We expect our methods have broad applications for functional biopharmaceutical development in mammalian cells.

1825 Pressler St, Sarofim Research Building, Houston TX 77030

E-mail: xin.ge at uth.tmc.edu; Phone: 713-500-2403

© 2022-2024 by Ge Lab

The opinions and views contained on this website are solely of the Ge Lab, and do not reflect the opinions or views of The University of Texas Health Science Center at Houston, nor those of UT Physicians. Neither UTHealth nor UT Physicians exert editorial control over this website, nor make any representations as to the accuracy or completeness of the information contained herein.

bottom of page